Characterization of nanoMIL-89. (A) Powder X-ray …
SEM analysis of solid nanoMIL-89 revealed ovoid nanoparticles of length 82.5 ± 20.2 nm and width 31.4 ± 6.6 nm (n = 20 nanoparticles from 3 consecutive batches of nanoMIL-89) consistent with the ...
Internalization of Metal–Organic Framework Nanoparticles in …
The uptake of nanoMIL-89 by PAECs and PASMCs was first assessed by inverted light microscopy at different time points (1, 3 and 7 days), under normal and inflammatory conditions induced by LPS (Figure 4 and Figure S1). As shown in Figure 4, nanoMIL-89 uptake increased with time in a concentration-dependent manner in both cell types. The …
Thông tin về vật liệu cac bua
Cacbua Boron (B4C) có độ cứng cao hơn alumina hoặc silicon carbide. Sản phẩm oxy hóa của nó (B2O3) cung cấp một làn da bảo vệ ở nhiệt độ cao (> 800oC). Do có độ cứng cao và khả năng chống mài mòn, boron cacbua được ứng dụng trong các ứng dụng nhiệt độ thấp như máy mài bánh ...
(PDF) Evaluation of Metal-Organic Framework MIL-89 …
Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 – 300 µM) at 4 hours post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24 ...
NanoMaterials Integration Lab
NanoMIL is equipped with a 6,000 square feet, class-100 nanofabrication facility and more than 20 pieces of major research instrumentation for fabrication and characterization. The Lab has experienced rapid growth in its level of technology, infrastructure and funding. It enjoys research partnerships with academia, national labs, and industry.
ResearchGate
Sil@nanoMIL-89 showed statistically signi cant e ects on the viability of human endothelial cells a er 24 h incubation (Fig. 3 and Supplementary Fig. 3). In addition, as we have shown previously ...
Internalization of Metal-Organic Framework …
Microscopic images showed cellular internalization of nanoMIL-89, packaging into endocytic vesicles, and passing to daughter cells during mitosis. …
Metal-organic framework (MOF) nanomedicine preparations …
Both nanoMIL-89 and sil@nanoMIL-89 were relatively non-toxic when incubated with human endothelial cells for 24 hours. Finally, the vasodilator effect of sil@nanoMIL-89 was measured over 8 hours using isolated mouse aorta. Consistent with drug release kinetics, sil@nanoMIL-89 induced vasodilation after a lag phase of >4 …
Studies on metal-organic framework (MOF) …
This study presents the first evaluation of a promising nanoformulation (highly porous iron-based metal-organic framework (MOF); nanoMIL-89) as a carrier for …
bioRxiv preprint doi: https://doi/10.1101/718478; …
The sildenafil nanoMIL-89 loading procedure, to produce sil@nanoMIL-89, was conducted as follows: 5 ml of a 1 mg/ml sildenafil solution was prepared in PBS (pH 7.4; Sigma Aldrich, UK), then 20 mg of nanoMIL-89 was added to the solution and incubated on a shaker at room temperature for 16-18 hours. The concentration of sildenafil was selected
Evaluation of Metal-Organic Framework MIL-89 …
In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 - 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated …
shell drug nanocarriers using solid-state NMR …
TEM images of nanoMIL-100(Al) degraded 48 hours in PBS solution. All TEM imaged show no dissolution of the nanoparticles. Degradation in PBS occurs through the formation of holes in the NPs. Solid-state NMR Spectroscopy The 27Al MAS and MQMAS NMR spectra were recorded at 20 T using a H/X/Y 3.2 mm double-
Internalization of Metal–Organic Framework …
the effects of nanoMIL-89 on cell viability and inflammatory responses, to highlight the safety and efficacy of iron-based MOF nanoparticles as future therapeutic tools in many CVDs. 2. Materials and Methods 2.1. Preparation and Chemical Analysis of NanoMIL-89 NanoMIL-89 was prepared following the previously published procedure by Mohamed et
Solid-State NMR Spectroscopy: A Key Tool to Unravel the …
The nanoMIL-100(Al) was impregnated with two different F-labeled lipid conjugates: methyl perfluorooctanoate (FO), which is supposedly small enough to enter in the pores of the MOF, and 1-palmitoyl-2-(16-fluoropalmitoyl)-sn-glycero-3-phosphocholine (FP), which is supposedly too large to enter in the pores of the MOF (Figure 11 a,b).
Degradation mechanism of metal-organic framework …
22 nanoMIL-100 drug carrier in biological-mimicking phosphate medium. By using solid-state NMR 23 (ssNMR) spectroscopy, we found that the first step of nanoMIL-100(Al) degradation is the
Degradation Mechanism of Metal–Organic …
The X-ray absorption near-edge structure (XANES) spectroscopy study of nanoMIL-100(Fe) degradation corroborates the hypothesized alteration mechanism of …
Christian Rassmuson
mars 2012–jan. 20152 år 11 månader. Stockholm, Sweden. Resonsible for expanding business within the intertechnology group in Inkom. Main focus is to target technology driven projects on the scandinavian market. Target areas such as defence, space, aviation, offshore, train and other ruggidized applications on the industrial market.
Carbide – Wikipedia tiếng Việt
Carbide. Trong hóa học, carbide (bắt nguồn từ từ tiếng Pháp carbure /kaʁbyʁ/), [1], tiếng Anh: carbide) còn được viết là cacbua, [1] được dùng để nói một cách không rõ ràng tới một trong ba loại hợp chất sau: 1. Ion đa nguyên tử C …
Evaluation of Metal-Organic Framework MIL-89 …
In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. …
CaC2 + H2O → C2H2 + Ca(OH)2
CaC2 + 2H2O → C2H2 + Ca (OH)2. 2. Điều kiện phản ứng điều chế C2H2. Không có. 3. Hiện tượng phản ứng điều chế C2H2. Hiện tượng: Chất rắn màu đen canxi cacbua (CaC 2) bị hòa tan và sinh ra khí axetilen (C 2 …
Tài nguyên
Mật độ của cacbua vonfram (WC) là 15,7 g / cm3 và mật độ coban (Co) là 8,9 g / cm3. Do đó, khi hàm lượng coban (Co) trong hợp kim vonfram-coban (WC-Co) giảm, mật độ tổng thể sẽ tăng. Mặc dù mật độ của cacbua titan (TiC) nhỏ hơn so với cacbua vonfram, nó chỉ 4,9 g / cm3, vì vậy nếu TiC ...
Enzyme Encapsulation in Mesoporous Metal Organic …
NanoMIL-101 and MP8@nanoMIL-101 were further charac-terized by nitrogen porosimetry at 77 K (Figure S3), leading to BET surface areas of 2550 m2 g 1 and 1510 m2g 1, respec-tively.
Studies on metal–organic framework (MOF) …
This study presents the first evaluation of a promising nanoformulation (highly porous iron-based metal–organic framework (MOF); nanoMIL-89) as a carrier for …
Studies on metal–organic framework (MOF) …
This study presents the first evaluation of a promising nanoformulation (highly porous iron‐based metal–organic framework (MOF); nanoMIL‐89) as a carrier for the PAH‐drug …
(PDF) Metal-organic framework (MOF) nanomedicine preparations …
Sil@nanoMIL-89 was then shown to release sildenafil in a biphasic manner with an initial rapid release over 6 hours followed by a more sustained release over 72 hours. Both nanoMIL-89 and sil ...
Studies on metal-organic framework (MOF) nanomedicine
In this study, nanoMIL-89 was prepared and charged with a payload of sildenafil (generating Sil@nanoMIL-89). Sildenafil release was measured by Enzyme-Linked Immunosorbent Assay (ELISA), and its effect on cell viability and dilator function in mouse aorta were assessed. Results showed that Sil@nanoMIL-89 released sildenafil over 6 h, …
New insights on the supramolecular structure of highly porous …
The 27 Al MQMAS NMR spectrum of the nanoMIL-100(Al) recorded at moderate static magnetic field (9.4 T, Fig. S2, ESI†) is similar to that reported earlier for micron-sized MIL-100(Al) recorded at 11.7 T. 12 The 27 Al MQMAS NMR spectrum of nanoMIL-100(Al) recorded at 20 T interestingly has increased resolution which reveals the presence of an ...
NanoMIL-100(Fe) containing docetaxel for breast cancer therapy
DTX-loaded nanoMIL-100 (Fe) showed 67% and 45% cell viability in 0.01 and 0.1 μg/mL concentrations of DTX, respectively. In contrast, the IC 50 range of free DTX at this time was between 1 and 10 μg/mL with cell viability of 54% and 46%, respectively.
Increased Thermal Conductivity in Metal-Organic Heat …
The MOHCs with nanoMIL-101(Cr)/GO and AGO were synthesized using the same procedure previously reported by our group 13, except replacing the modulator by GO or AGO. Cr(NO 3 ) 3 .9H 2 O (330 mg, 0.82 mmol), terephathalic acid (136.9 mg, 0.82 mmol), and varied amounts of GO and amino GO (4, 8, and 12 mg) were reacted in 25 …
Tại sao cacbua vonfram là một vật liệu công cụ lý tưởng?
Cacbua vonfram WC-Co có một lợi thế độc đáo về cả độ cứng và độ dẻo dai. Vonfram cacbua (WC) tự nó có độ cứng rất cao (vượt quá corundum hoặc alumina) và độ cứng của nó hiếm khi giảm khi nhiệt độ hoạt động tăng. Tuy nhiên, nó thiếu đủ độ dẻo dai, là …
Phân tích kỹ thuật phay vi mô trên vật liệu cacbua bằng máy …
Lực cắt, chất lượng bề mặt và độ mòn của dụng cụ được phân tích. Nội dung ẩn giấu. 1 Thiết bị thử nghiệm và lịch trình thử nghiệm của phay vi mô PDC. 2 Kết quả thử nghiệm và phân tích vi phay PCD. 3 Chất lượng bề mặt của vi phay PCD. 4 Kết luận cho đến nay.
Thị trường cacbua canxi
Phân tích thị phần & quy mô thị trường cacbua canxi - Xu hướng & dự báo tăng trưởng (2023 - 2028) Thị trường cacbua canxi được phân khúc theo ứng dụng (khí axetylen, canxi xyanamide, chất khử và khử nước, chất khử lưu huỳnh và khử oxy và các ứng dụng khác), công nghiệp người dùng cuối (hóa chất, luyện kim, thực ...
Macrophage Cell Membrane Coating on Piperine-Loaded …
1. Introduction. Nanotechnology is a rapidly developing field that brings promising opportunities to human cancer diagnosis and treatment. Nanoparticles can play a significant role as a drug delivery system for cancer treatment [].This system can be classified into three groups: inorganic nanomaterials (including iron oxide, gold …
Nanomaterials | Free Full-Text | Internalization of …
Nanomedicine is defined as the employment of nanoparticles (NPs, i.e., particles with a diameter between 1 and 150 nm) often as drug delivery vehicles or for …
Nanomaterials | Free Full-Text | Internalization of Metal
Moreover, nanoMIL-89 showed anti-inflammatory activity without any significant cytotoxicity. Our results indicate that nanoMIL-89 formulation may offer promising therapeutic opportunities and set forth a new prototype for drug delivery not only in CVDs, but also for other diseases yet incurable, such as diabetes and cancer. ...
Internalization of Metal–Organic Framework …
We have previously developed an enhanced formulation of nanoMIL-89 and characterized its physio-chemical proprieties and stability. NanoMIL-89 has also shown relative safety …
Doxorubicin-Loaded Metal-Organic Frameworks …
3.1. DOX Encapsulation in nanoMIL-100(Al) MIL-100(Al) nanoMOFs with mean hydrodynamic diameters of 260 ± 8 nm were successfully synthesized. They exhibited facetted morphology (Figure 1 A) and a crystalline structure according to TEM and PXRD investigations, respectively. The Brunauer–Emmett–Teller (BET) surface area reached …
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In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were …
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