Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type.
6. Let T : V → V be alinearoperator ofa vector spaceV.Suppose that V = R(T)⊕W and W is T-invariant. (1) Prove that W ⊆ N(T). (2) Show that if V is finite dimensional, then W = N(T). (3) Show that if V is infinite dimensional, then (2) fails by consid-ering the real vector space V = {(a 1,a 2,...)|a i ∈ R} and the left shift operator T ...
cd14819 (PSSM ID: 271349): Conserved Protein Domain Family Translin, Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse ortholog), is a paralog of its binding partner protein TRAX (translin-associated factor-X) and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA …
Citing CDD. Lu S et al. (2020). "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48 (D1) :D265-D268. pfam16353 (PSSM ID: 435294): Conserved Protein Domain Family DUF4981, This family consists of uncharacterized proteins around 1000 residues in length and is mainly found in various …
tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors. This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the …
Citing CDD. Jiyao W et al. (2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51 (D1) :D384-D388. pfam13610 (PSSM ID: 433347): Conserved Protein Domain Family DDE_Tnp_IS240, This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.
cd07909: YciF. Download alignment. YciF bacterial stress response protein, ferritin-like iron-binding domain. YciF is a bacterial protein of unknown function that is up-regulated when bacteria experience stress conditions, and is highly conserved in a broad range of bacterial species. YciF has a ferritin-like domain.
Conserved Protein Domain FamilyECF_trnsprt. ? Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in …
This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Medioniviridae, order Nidovirales. Member viruses have a viral envelope and (+)ssRNA genome. The Medioniviridae subgenera includes Turrinivirus and Balbicanovirus. The structure of Medioniviridae RdRp contains a RdRp domain as well …
cd02248 (PSSM ID: 239068): Conserved Protein Domain Family Peptidase_C1A, Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W)
Jiyao W et al. (2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51 (D1) :D384-D388. TIGR02356 (PSSM ID: 274094): Conserved Protein Domain Family adenyl_thiF, Members of the HesA/MoeB/ThiF family of proteins (pfam00899) include a number of members encoded in the midst of thiamine biosynthetic …
Jiyao W et al. (2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51 (D1) :D384-D388. pfam10604 (PSSM ID: 431388): Conserved Protein Domain Family Polyketide_cyc2, This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis.
Conserved Protein Domain FamilyBet_v1-like. ? This family includes the ligand binding domain of Bet v 1 (the major pollen allergen of white birch, Betula verrucosa) and related proteins. In addition to birch Bet v 1, this family includes other plant intracellular pathogenesis-related class 10 (PR-10) proteins, norcoclaurine synthases (NCSs ...
1EXC_B 165 G D Y Y S V M G L P I S K T M R A L R H F 185 Bacillus subtilis XP_001416332 215 G S M D G V M G L D A Q T V E R L L N E F 235 Ostreococcus lucimarinus CCE9901 Q01DW4 190 G S L D G V M G L D A K T V E R L L D E L 210 Ostreococcus tauri CBN74303 188 G S M D S V M G L S K A L V L E L L E K h …
Citing CDD. Lu S et al. (2020). "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48 (D1) :D265-D268. pfam05345 (PSSM ID: 398814): Conserved Protein Domain Family He_PIG, This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins.
cd15837 (PSSM ID: 276933): Conserved Protein Domain Family TNFRSF26, TNFRSF26 (also known as tumor necrosis factor receptor homolog 3 (TNFRH3) or TNFRSF24) is predominantly expressed in embryos and lymphoid cell types, along with its closely related TNFRSF22 and TNFRSF23 orthologs, and is …
Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally …
pfam12571: DUF3751. Download alignment. Phage tail-collar fibre protein. This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.
Citing CDD. Jiyao W et al. (2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51 (D1) :D384-D388. cd11378 (PSSM ID: 211390): Conserved Protein Domain Family DUF296, This domain is found in proteins that contain AT-hook motifs, which suggests a role in DNA-binding for the proteins as a whole.
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This enzyme from Arabidopsis thaliana (AtUGlyAH) has been shown to bind a Mn2+ ion, via the C-terminal cupin domain, which acts as a molecular anchor to bind (S)-ureidoglycine, and its binding mode dictates the enantioselectivity of the reaction. The structure of AtUGlyAH shows a bi-cupin fold with a conserved "jelly roll-like" beta-barrel …